IVIT   27842
INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System
Autor/es:
MIRAGLIA, MARÍA CRUZ; DELPINO, M. VICTORIA; RODRÍGUEZ, ANA M.; GIAMBARTOLOMEI, GUILLERMO H.; MIRAGLIA, MARÍA CRUZ; DELPINO, M. VICTORIA; RODRÍGUEZ, ANA M.; GIAMBARTOLOMEI, GUILLERMO H.
Revista:
NEUROSCIENCE
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2019 p. 264 - 273
ISSN:
0306-4522
Resumen:
Abstract?Neurobrucellosis, which is themost morbid formof brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise.This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes placeupon Brucella infection. © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.