Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System

MIRAGLIA, MARÍA CRUZ; DELPINO, M. VICTORIA; RODRÍGUEZ, ANA M.; GIAMBARTOLOMEI, GUILLERMO H.; MIRAGLIA, MARÍA CRUZ; DELPINO, M. VICTORIA; RODRÍGUEZ, ANA M.; GIAMBARTOLOMEI, GUILLERMO H.

NEUROSCIENCE

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2019 p. 264 - 273

0306-4522

Abstract?Neurobrucellosis, which is themost morbid formof brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise.This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes placeupon Brucella infection. © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.