MMUNE MEDIATORS REGULATE NEUTROPHILS FUNCTIONS IN PATIENTS WITH TB ACCORDING TO DISEASE SEVERITY

MORELLI P; MARTIN CANDELA; DONNOLI L; BAZAN ANA; MARTINENA, CAMILA BELEN; TATEOSIAN, NANCY L.; AMIANO, NICOLAS; CIALLELLA, L; MUSELLA, R; DE CASADO, GRACIELA C; PALMERO, DJ; GARCIA, VE

Workshop; "Pathogenic microbes-host interactions: highlights in intracellular traffic"; 2022

Mycobacterium tuberculosis (Mtb) causes nearly 10 million of new cases of tuberculosis (TB) and 1.6 million of deaths per year. Neutrophils infected with Mycobacterium tuberculosis (Mtb) predominate in patient´s lungs. Neutrophilic infiltration represents a characteristic feature of severe tuberculosis (TB) but neutrophil biology during TB remains poorly understood. Autophagy is crucial for several neutrophil functions and can be modulated by different mediators. Human immune responses against Mtb involve different cell types and immune mediators. Underlying TB clinical manifestations, individual immunological profiles can be identified in patients according to their immune responses during infection.