INVESTIGADORES
DUARTE Alejandra Beatriz
congresos y reuniones científicas
Título:
A B-cell superantigen induces the apoptosis of murine and human malignant B cells
Autor/es:
DUARTE ALEJANDRA; LORENZO DANIELA; MUNDIÑANO JULIANA; BERGUER PAULA; SIELECKI ALEJANDRO; ALEMÁN MERCEDES; NEPOMNASCHY IRENE; PIAZZON ISABEL
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión anual SAIC-SAI-SAFFE; 2016
Institución organizadora:
Sociedad Argentina de Investigaciones Clínicas
Resumen:
B-cell superantigens (Sags) are bacterial and viral proteins which affect immune responsiveness binding conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions inducing apoptosis of normal cognate B cells. We have demonstrated for the first time that T-cell Sags induce the apoptosis of cognate malignant T cells.Exposure to bacterial T Sags in vivo increases lymphoma-bearing mice survival. In the present study we investigated whether protein L (PpL), B-cell Sag that interacts with κ+ bearing cellsare able to induce the apoptosis in spontaneous murine lymphoma B cells and human Daudi cells. Results:PpL induced apoptosis (measured by Annexin V-FITC) in murine κ+lymphoma B both in vitro (p
