Poloxamines and n-methylated poloxamines as efavirenz micellar nanocarriers: a comparative study

CHIAPPETTA D.A.; ALVAREZ-LORENZO C.; REY-RICO A.; TABOADA P.; CONCHEIRO A.; SOSNIK A.

Malta

Congreso; 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology.; 2010

Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e. V. (APV), Association de Pharmacie Galénique Industrielle (APGI) and Associazione Docenti Ricercatori Italiani di Tecnologie e Legislazione Farmaceutiche Dipartimento di Scienze Farmaceutiche.

The aim of this work was to characterize the self-associative behavior of a variety of N-methylated poloxamines and to compare pristine and N-methylated poloxamines regarding the encapsulation and in vitro delivery of efavirenz (EFV). This lipophilic drug, which is a first-choice antiretroviral used for the treatment of HIV/AIDS, shows relatively low oral absorption and bioavailability (40-45%) and a high inter-individual variability. Development of aqueous formulations with improved drug solubility may notably improve the management of the HIV infection in children.