Effects of Carvedilol on Cardiovascular Parameters and Blood Pressure Variability in Spontaneously Hypertensive Rats

DEL MAURO J.S.; POLIZIO A.; BERTERA F.; CHIAPPETTA D.A.; TAIRA C.; HOCHT C.

Orlando

Congreso; High Blood Pressure Research 2011 Scientific Sessions; 2011

Clinical evidences suggest that traditional beta blockers are not effective for attenuation of blood pressure variability (BPV), a risk factor for target organ damage associated to hypertension. Extrapolation of these results to third generation beta blockers (eg carvedilol) seems not to be adequate considering the existence of great pharmacokinetic and pharmacodynamic differences between beta blocker agents. Carvedilol induced a greater hypotensive response and a greater vascular sympatholytic activity. Carvedilol also dramatically reduced short-term BPV. Considering that both degree of hypertension and high BPV contributes to target organ damage in hypertensive subjects, our results suggest that treatment with carvedilol may effectively prevent complications associated to the hypertensive stage.