On-line Preconcentration / Speciation and Determination of Chromium in Parenteral Solutions by Inductively Coupled Plasma Optical Emission Spectrometry

R.A. GIL, S. CERUTTI, J.A. GÁSQUEZ, R.A. OLSINA, L.D. MARTINEZ

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY

Elsevier

Año: 2005 vol. 60 p. 531 - 535

0584-8547

A method for the preconcentration and speciation of chromium was developed. On-line preconcentration and determination were obtained using inductively coupled plasma optical emission spectrometry (ICP-OES) coupled with flow injection (FI). To determinate the chromium (III) present in parenteral solutions, chromium was retained on activated carbon (AC) at pH 5.0. On the other hand, a step of reduction was necessary in order to determine total chromium content. The Cr(VI) concentration was then determined by difference between the total chromium concentration and that of Cr(III). A sensitivity enrichment factor of  70-fold was obtained with respect to the chromium determination by ICP-OES without preconcentration. The detection limit for the preconcentration of 25 ml of sample was 29 ng l –1. The precision for the 10 replicate determinations at the 5 mg l –1 Cr level was 2.3% relative standard deviation (RSD), calculated with the peak heights. The calibration graph using the preconcentration method for chromium species was linear with a correlation coefficient of 0.9995 at levels near the detection limits up to at least 60  mg l –1. The method could be applied to the determination and speciation of chromium in parenteral solutions.