INVESTIGADORES
DAVICINO Roberto Carlos
congresos y reuniones científicas
Título:
GALECTIN-1?DRIVEN TOLEROGENIC PROGRAMS AGGRAVATE YERSINIA ENTEROCOLITICA INFECTION BY REPRESSING ANTIBACTERIAL INMUNITY
Autor/es:
DAVICINO RC; MENDEZ-HUERGO, SANTIAGO; ELIÇABE, JAVIER; AUTENRIETH, INGO; MARÍA S. DI GENARO; GABRIEL A. RABINOVICH
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión anual Sociedades Biomédicas; 2017
Institución organizadora:
Sociedades Biomédicas
Resumen:
Yersinia Enterocolitica (Ye) Is An Enteropathogenic BacteriumThat Causes Gastrointestinal Disorders. To Subvert The Host?s ImmuneResponse, Ye Uses A Type Iii Secretion System And EffectorProteins, Called Yersinia Outer Proteins (Yops), That Modulate ActivationAnd Survival Of Immune Cells. In This Study, We Show ThatGalectin-1 (Gal-1), An Immunoregulatory Lectin Widely ExpressedIn Mucosal Tissues, Contributes To Ye Pathogenicity By UnderminingProtective Antibacterial Responses. We Found Higher ExpressionOf Gal-1 In The Spleen And Peyer?s Patches (Pps) Of MiceInfected Orogastrically With Ye Compared With Noninfected Hosts(P
