Effect of a fraction obtained from Larrea divaricata on dectin-1 receptor in Candida albicans infection model.

MARTINO R; DAVICINO R; MATTAR A, ; CASALI Y ; MICALIZZI B

Ciudad de la Punta, San Luis

Congreso; XXVIII Reunión Anual Científica de la Sociedad de Biología de Cuyo; 2010

Socieda dde Biología de Cuyo

Larrea divaricata is a shrub with several applications in argentinean folk medicine. The aim of this work was to test the role of â-glucan receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata folk medicine. The aim of this work was to test the role of â-glucan receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata is a shrub with several applications in argentinean folk medicine. The aim of this work was to test the role of â-glucan receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata â-glucan receptor (dectin-1) on macrophage (MO) of mice infected with C. albicans and treated with a fraction obtained from L. divaricata albicans and treated with a fraction obtained from L. divaricata C. albicans and treated with a fraction obtained from L. divaricataand treated with a fraction obtained from L. divaricata (F1). Healthy and infected mice were treated with: a) PBS; b) F1; c) antibody against dectin-1(15Y9); d) F1+15Y9. The 15Y9 was administered during 4 days before infection. Treatment with F1 was started 24 h after infection and extended during 3 days. MO were harvested and, liver, spleen and kidney were removed and homogenated for CFU counts. Phagocytosis activity, superoxide production by NBT test, viability by MTT test and CR3 expression on MO were performed. Results show that 15Y9 increases phagocytosis in all groups (p