In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (jarilla) on mouse peritoneal macrophages.

MARTINO, RENZO; DAVICINO ROBERTO; AIDA MATTAR; YOLANDA CASALI; SILVIA G. CORREA; CLAUDIA ANESINI; BLAS MICALIZZI

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2010 vol. 32 p. 125 - 132

0892-3973

Background and aim: Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentina.Material and methods: We isolated different fractions of L. divaricata aqueous extract containing minoramounts of NDGA, and we analyzed these fractions on mouse macrophages.Results: We showed that a fraction without NDGA was capableof activating macrophages, principallythrough the production of mitochondrial anion superoxide and H2O2. This could be important in thedefense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action.Conclusion: These results indicate that NDGA was not the compound responsible for the immunomodulatoryaction exerted by the aqueous extract from L. divaricata.