The Multiple Faces of Nitric Oxide in Chronic Granulomatous Disease: A Comprehensive Update

GARAY, JUAN AGUSTIN; JUAN SILVA; DI GENARO M.S; DAVICINO RC

Biomedicines

MDPI

Lugar: Bazel; Año: 2022 vol. 10

2227-9059

Nitric oxide (NO), a signaling molecule, regulates multiple biological functions, includinga variety of physiological and pathological processes. In this regard, NO participates in cutaneousinflammations, modulation of mitochondrial functions, vascular diseases, COVID-19, neurologicdiseases, and obesity. It also mediates changes in the skeletal muscle function. Chronic granulomatousdisease (CGD) is a primary immunodeficiency disorder characterized by the malfunction ofphagocytes caused by mutations in some of the genes encoding subunits of the superoxide-generatingphagocyte NADPH (NOX). The literature consulted shows that there is a relationship between theproduction of NO and the NADPH oxidase system, which regulates the persistence of NO in themedium. Nevertheless, the underlying mechanisms of the effects of NO on CGD remain unknown. Inthis paper, we briefly review the regulatory role of NO in CGD and its potential underlying mechanisms.