In vivo immunomodulatory effect of Tilia x viridis extracts on normal lymphocyte proliferation: a direct and an indirect action.

ROBERTO DAVICINO; GABRIELA ZETTLER; MARGARITA RODRIGUEZ BRIZI; CARLA MARRASSINI; GRACIELA FERRARO; ROSANA FILIP; CLAUDIA ANESINI

PHYTOTHERAPY RESEARCH

JOHN WILEY & SONS LTD

Lugar: Londres; Año: 2011 vol. 25 p. 1342 - 1347

0951-418X

The flowers of Tilia species have been used in Europe for many years to treat colds, bronchitis, fever,inflammations and influenza. It is well known that lymphocytes play a role in acquired immunity related topathogens and tumor cells attachment. The aim of this study was to determine the effect of an aqueous (AE) anda dichloromethane extract (DM) from Tilia x viridis which is widely used and distributed in Argentina, onnormal murine lymphocyte proliferation after being administered to mice. Both extracts presented a stimulatoryeffect on normal murine lymphocyte proliferation. The effect exerted by DM was principally related tomacrophage activation, meanwhile AE exerted an important direct effect on lymphocytes related to the rutinpresence. The stimulating effect, exerted on normal lymphocytes was due to a protective effect of apoptosis andalso to cell IL2 production.