Vicenin-2, a Potential Anti-inflammatory Constituent of Urtica circularis.

MARRASSINI C, ; DAVICINO R, ; ACEVEDO C, ; ANESINI C, ; GORZALCZANY S,; FERRARO G

JOURNAL OF NATURAL PRODUCTS

AMER CHEMICAL SOC

Lugar: California; Año: 2011 vol. 74 p. 1503 - 1507

0163-3864

Vicenin-2 (1), a flavonoid glycoside, was isolated and identified from an ethanol extract of the aerial parts of Urtica circularis. This crude extract was found to possess significant anti-inflammatory activity in a carrageenan-induced rat hind paw edema model (41.5% inhibition at a dose of 300 mg/kg; ip). The effects of 1 on several inflammatory mediators were investigated. In cultured murine macrophages, this compound modified LPS-induced total nitrite and TNF-á production, in addition to the LPS-induced translocation of the nuclear factor NF-êB.