AMYLOID-BETA INDUCES ENDOTHELIAL ENDOPLASMIC RETICULUM STRESS IN ASSOCIATION WITH BLOOD-BRAIN BARRIER DISRUPTION IN EXPERIMENTAL MODELS OF ALZHEIMER'S DISEASE.

POMILIO C; PRESA J; GONZALEZ PEREZ N; VINUESA A; BENTIVEGNA M; GREGOSA A; KIM KS; GALVÁN V; BEAUQUIS J; SARAVIA F

Congreso; Reunión de Sociedades de Biociencias 2020; 2020

Sociedad Argentina de Investigación Clínica

Alzheimer?s disease (AD) is the leading cause of dementia. Among other histopathological hallmarks, it is characterized by the abnormal accumulation of Amyloid-β (Aβ) peptides. Vascular alterations and blood-brain barrier disruption are also evidenced in AD patients, in close association with perivascular amyloid deposits, which are composed mainly of Aβ 1-40. In this study we characterized the progression of vascular alterations in the hippocampus of PDAPP-J20 mice, a validated transgenic model for AD. We found a significant increment in morphological alterations in vessels from AD mice compared to age-matched controls (p