Alzheimer's Disease as a metabolic pathology: Inflammation and insulin resistance in a mouse model of AD. In vivo and in vitro approaches.

BENTIVEGNA M; GREGOSA A; VINUESA A; POMILIO C; PRESA J; SARAVIA F; BEAUQUIS J

Congreso; Reunión de Sociedades de Biociencias 2020; 2020

Sociedad Argentina de Investigación Clínica

Insulin resistance and chronic inflammation are frequently associated with the development of cognitive disorders and neurodegenerative diseases such as Alzheimer´s disease (AD). However, it is not yet clear whether there is a causal link between these two factors, and which one appears earlier in the pathology. Our objective was to study metabolic parameters and inflammation in a possible brain insulin resistance context in a transgenic model of AD, the PDAPP-J20 mouse at the age of 8 months. We hypothesized that an inflammatory environment could trigger insulin resistance in the brain, neurodegeneration and cognitive impairment. We found lower glycemic levels and altered phosphorylation levels of AKT measured by Western Blot -an indicator of the insulin signaling status- in the hippocampus of transgenic mice compared with control mice (p