EFFECTS OF A HIGH-FAT DIET IN A MOUSE MODEL OF ALZHEIMER´S DISEASE.

BENTIVEGNA M; VINUESA A; POMILIO C; PRESA J; GREGOSA A; SARAVIA F; BEAUQUIS J

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2019

Sociedad Argentina de Investigación Clínica

Insulin resistance and obesity, associated to the consumption of hyperlipidic diets, are considered risk factors for the development of cognitive disorders and neurodegenerative diseases such as Alzheimer's disease (AD). Insulin resistance, inflammation and cognitive dysfunction are common manifestations in the context of both neurodegenerative and metabolic pathologies. Our objective was to study the effects of the exposure to a moderately high-fat diet (HFD), from 6,5 to 8 months of age, on cognitive performance and hippocampal glial and neuronal changes in a transgenic model of AD, the PDAPP-J20 mouse. Interestingly, HFD exposure did not induce changes in body weight at the end of the protocol. Although we found that diet had no effect on glucose blood levels, transgenic mice showed decreased glycemia compared to non-transgenic groups (p