Impaired microglial autophagy in experimental Alzheimer's disease.

SARAVIA F; POMILIO C; VINUESA A; GOROJOD RM; PORTE ALCON S; PRESA J; GREGOSA A; BONIFACINO J; KOTLER ML; BEAUQUIS J

Porto

Congreso; GLIA Porto 2019; 2019

The presence of neuroinflammation is a hallmark in neurodegenerative diseases as Alzheimer?s (AD). The microglial activation plays a crucial role responding to toxic aggregated amyloid peptides and participating in their clearance. The mechanisms implicated are still elusive. Although most studies assessing the role of autophagy in neurodegeneration and brain aging have focused on neurons, emerging studies suggest that autophagy may also modulate the glial cell function. Here, our aim was to study the role of autophagy in microglia during the neurodegenerative process. The hippocampus of 15 month-old PDAPPJ20 mice, transgenic model of AD, showed hyper reactive Iba1+cells mobilized around amyloid deposits. Compared with age matched controls, microglia in AD mice lost the phagocytic marker CD68 (p