GLIAL METABOTROPIC GLUTAMATE RECEPTOR (mGlu3R) DYSFUNCTION IN ALZHEIMER'S: IMPLICATIONS FOR sAPP-MEDIATED Abeta CLEARANCE

RUDI MJ; TURATI J; RAMIREZ D; CARNIGLIA L; SABA J; CARUSO C; BEAUQUIS J; SARAVIA F; LASAGA M; DURAND D

Córdoba

Congreso; Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2018

Sociedad Argentina de Investigación en Neurociencias

Astroglial mGlu3R promotesneuroprotective effects, such asreleasingneurotrophinsAPPα and increasingAβuptake.We aimed to study whether mGlu3R alterations could be associated with AD progression in an AD mice model. Evidence for mechanisms involved insAPPα-mediated Aβ elimination is provided here as well.mGlu3R protein levels remain stable during aging in non-transgenic (NTg) mice, whereas they progressively decrease with age in PDAPP-J20 (Tg) animals (p