Early exposure to a high fat diet promotes cognitive impairment, neuroinflammation and decreased hippocampal plasticity. Possible implication of microglia- derived exosome- like extracellular vesicles.

VINUESA A; BENTIVEGNA M; CALFA, G; FILIPELLO F; POMILIO C; BONAVENTURA M; LUX-LANTOS V; GREGOSA A; PRESA J; MATTEOLI M; BEAUQUIS J; SARAVIA F

Mar del Plata

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2018

Sociedad Argentina de Investigación Clínica

Western dietary habits including high fat-industrialized foods are increasinglyrepresented in juvenile populations and constitute one of the factors that affect brain health, potentially leading to long lasting effects. Adolescence, characterized by brain maturation and behavioral changes, is particularly vulnerable to the environment. Hence, our aim was to study the impact of an early exposure to a high fat diet (HFD) on mouse hippocampal plasticity and cognition. To that end, C57BL/6J male mice were exposed to HFD for 6 weeks since weaning. Glycemia and seric proinflammatory IL1β were higher in HFD mice (p