ASTROCYTIC INSULIN SIGNALING AND INFLAMMATION IN EXPERIMENTAL ALZHEIMER’S DISEASE

BENTIVEGNA M; GREGOSA A; ROSSI S; VINUESA A; BONAVENTURA M; POMILIO C; PRESA J; LUX-LANTOS V; SARAVIA F; BEAUQUIS J

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021; 2021

Sociedad Argentina de Investigación Clínica (SAIC)

Insulin resistance (IR) and chronic inflammation are associated with the development of cognitivedisorders and neurodegenerative diseases such as Alzheimer's (AD). However, it is not clear whether thereis a causal link between these factors, which one appears earlier in the pathology or if either one of themis triggered by the increasing circulating levels of Aβ or amyloid deposits in early AD. Our objective was tostudy the metabolic and inflammatory status of a model of AD, the PDAPP-J20 mouse at the age of 8months. We also treated a WT group with a high fat diet (HFD) as a positive control for IR. Our hypothesiswas that in early stages of AD, the brain develops IR with astrocytes showing reactivity and impairedinsulin signaling. Final body weight, glycemia and insulinemia were not affected by genotype or HFD. Theopen-field test showed an anxious-like behavior in transgenic and in HFD-fed mice. Insulin signalingmeasured by pAkt/Akt ratio was decreased in the hippocampus of AD mice (p