NEUTROPHILS FROM CHILDREN WITH ACUTE COVID-19 EXHIBIT AN INFLAMMATORY SIGNATURE WITH A DISTINCT EXPRESSION OF HIGH AFFINITY RECEPTOR FOR IgG

SEERY, VANESA; RAIDEN SILVINA; ALGIERI, S; FILIPO, D; DE CARLI, N; CAIROLI H; CHIOLO, MJ; DI LALLIA, S; GRISOLIA, N; GREGORIO, G; LATTNER, J; COLL, P; ROLON, MJ; SANANEZ, I; HOLGADO P; FERRERO FERNANDO; GEFFNER, JORGE; ARRUVITO LOURDES

Buenos Aires

Congreso; Reunión anual de sociedades de Biociencias 2020; 2020

BACKGROUND: Children can be infected by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), being most pediatric cases mild but the reason underlying are still unknown. This study addressed the immunopathological characteristics of neutrophils from acute COVID-19 infected children. METHODS: Sixty acute COVID-19 mildly infected children (1-14 years-old) and 9 healthy infants were studied. A multiparametric flow cytometry from neutrophils was performed in whole blood. Levels of IL-1β in supernatant culture from purified neutrophils and serum anti SARS-CoV-2 IgG were quantified by ELISA. RESULTS: A low expression of CD11b (p