KIR receptors and HLA-C in the maintenance of pregnancy

FLORES ANA CLAUDIA; MARCOS CINTIA YANINA; PALADINO NATALIA; ARRUVITO LOURDES; WILLIAMS FIONNUALA; MIDDLETON DEREK; FAINBOIM LEONARDO

Melbourne, Australia

Workshop; 14th International HLA and Immunogemnetics. Workshop.; 2005

The present study demonstrated that patients who have recurrent spontaneous  abortions (RSA) presented a decreased number of killer immunoglobulin-like  inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was  found increased in comparison with controls. Individuals AA will also be  homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction  with C1 ligands and therefore a weaker inhibition. The present study might support  that in RSA patients, the balance between inhibitory and activating receptors  present in natural killer cells is inclined toward an activating state that may  contribute to pregnancy loss.