Discovery of ionizing radiation-response and radiosensitivity biomarkers

BIOLATTI, V.; BARRIENTOS EDUARDS, S.Y.; LEBERLE, J.; BELLORA, N.; NEGRIN, L.; IBAÑEZ, I. L.

Congreso; Reunión de Sociedades de Biociencias 2020, LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC), LXVIII Reunión Anual de la Sociedad Argentina de Inmunología (SAI), Reunión Anual de la Sociedad Argentina de Fisiología (SAFIS); 2020

SAIC, SAI, SAFIS

In view of the widely use of ionizing radiation (IR) in different fields, we aimed to establish a pipeline to study at a genomic level: IR-exposure, absorbed IR-dose and intrinsic radiosensitivity. Moreover,this study could help to detect the responsible molecular pathways of the biological IR effects. We performed a meta-analysis of raw data from public microarrays of different IR-exposure conditions: ex vivo irradiated human peripheral white blood cells (WBC) of healthy individuals and cancer patients, as well as total body irradiation or localized radiotherapy patients. The analysis was assessed using R commander and Bioconductor packages. We identified 275 differentially expressed genes (DEGs) (FDR