Magnetic Combination Therapy: A New, Drug-Free Approach to Cancer Treatment

MICHAEL STANTON; BORJA HERRERO DE LA PARTE; EMILIO DE BIASI; FERNANDO PLAZAOLA; IRATI RODRIGO ARRIZABALAGA; EMMA N. WELBOURNE; ENIO LIMA JR.; JOSÉ Á. GARCÍA; DANIELA P. VALDÉS; TEOBALDO E. TORRES; ROBERTO D. ZYSLER; RUSSELL COWBURN

Washington, DC

Conferencia; 2019 Joint MMM-Intermag Conference; 2019

IEEE Magnetics Society

Magnetic hyperthermia and magneto-mechanical destruction are two emerging cancer therapies [1, 2]. We studied the combination of these treatments to develop a new, more efficient therapy. For hyperthermia, we synthesized magnetic iron-oxide nanoparticles (MIONs) by thermal decomposition [3]. They were later coated with DEXTRAN and DSPE-mPEG(2000) (mPEG). The MIONs were magnetically characterized and their size distribution was obtained by analyzing TEM images (Figure 1). Experimental specific absorption rate measurements were made in a custom-built AC magnetometer to define the characteristics of the field to be used for the magnetic hyperthermia experiments [4]. For magneto-mechanical destruction, we fabricated synthetic antiferromagnetic (SAF) microdiscs with perpendicular anisotropy using a combination of sputtering and lithography techniques [5]. The discs were magnetically characterized using MOKE and VSM and imaged by SEM (Figure 2). Cytotoxicity assays evaluated the cell viability of CC531 rat cell lines after incubation with un-coated, DEXTRAN-coated and mPEG-coated MIONs, along with the microdiscs. In vitro tests on the CC531 cells under the application of the cancer treatments were performed. Cell viability measurements were used to assess the cell-killing efficiency of hyperthermia and magneto-mechanical destruction individually compared with their combined effect.[1] A. Jordan, R. Scholz, P. Wust, Journal of Magnetism and Magnetic Materials, Vol. 201, p. 413 (1999)[2] R. Mansell, T. Vemulkar, D. C. M. C. Petit, Scientific Reports, Vol. 7, p.4257 (2017)[3] M.L. Mojica Pisciotti, E. Lima Jr., M. Vasquez Mansilla, Journal of Biomedical Materials Research Part B: Applied Biomaterials, Vol. 102, p.860 (2014)[4] E. Garaio, J.M. Collantes, F. Plazaola, Measurement Science and Technology, Vol. 25, p.115702 (2014)[5] T. Vemulkar, R. Mansell, D. C. M. C. Petit, R. P. Cowburn and M. S. Lesniak, Applied Physics Letters, Vol. 107, p.012403 (2015)