Strontium Titanate (SrTiO 3 ) Mesoporous Coatings for Enhanced Strontium Delivery and Osseointegration on Bone Implants

ANGELOMÉ, PAULA C.; BINDINI, ELISA; MUZZIO, NICOLÁS; MARTÍNEZ, ANGEL; GRZELCZAK, MAREK; ANDREOZZI, PATRIZIA; ESCOBAR, ANE; BORDONI, ANDREA V.; COY, EMERSON; MOYA, SERGIO E.

ADVANCED ENGINEERING MATERIALS (PRINT)

WILEY-V C H VERLAG GMBH

Año: 2019 p. 1801210 - 1801210

1438-1656

The incorporation of strontium (Sr) in titania enhances surface bioactivityand has a positive effect on pre-osteoblastic cell attachment, proliferation,and differentiation. Strontium titanate mesoporous films (SrTiMFs) with30% pore volume and a 20% Sr molar content have been prepared by theevaporation induced self-assembly method. SrTiMFs display a large internalsurface area available for exchange of Sr, which is released in cell mediaup to 44% within the first 8 h. SrTiMFs improve attachment of MC3T3-E1pre-osteoblastic cells, which show larger filopodia and more elongatedfeatures than cells attached to plain mesoporous titania films (MTFs).SrTiMFs also display improved cell proliferation and differentiation ratesindicating that overall Sr incorporation into mesoporous titania coatingscan lead to enhanced osseointegration during the early stages of bonetissue formation.