IMTIB 27019
INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Unidad Ejecutora - UE
artículos
Título:
Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
Autor/es:
FANTILLI, ANABELLA C.; MARCIANO, SEBASTIÁN; ZÁRATE, FABIÁN; GADANO, ADRIÁN; DEBES, JOSÉ D.; RÉ, VIVIANA E.; TRINKS, JULIETA; HADDAD, LEILA; PISANO, MARÍA B.
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2019 vol. 14
ISSN:
1932-6203
Resumen:
Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina.Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72).Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p
