IMTIB 27019
INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Unidad Ejecutora - UE
artículos
Título:
Kidney liver pathophysiological crosstalk: its characteristics and importance
Autor/es:
FERRERO-FERNÁNDEZ, ALBERTA; GIULIANI, SOFÍA; MUSSO, CARLOS G.; CAPALBO, OLIVIA; CASCIATO, PAOLA
Revista:
INTERNATIONAL UROLOGY AND NEFROLOGY
Editorial:
Springer Nature
Referencias:
Año: 2019 vol. 51 p. 2203 - 2207
ISSN:
0301-1623
Resumen:
AbstractThe kidney plays a crucial role in controlling the blood volume and pressure, electrolyte and acid?base balance, erythropoietinsecretion, as well as renin?angiotensin?aldosterone system activity. All these renal activities have important repercussionin the organism, explaining why morbidity and mortality rates are high in patients with significant renal dysfunction. In thissense, there are renal-induced liver damages in acute kidney injury, as well as liver-induced renal damages in hepatic disease.Ischemia, reperfusion, cytokine outflow, pro-inflammatory cascades, metabolic acidosis, oxidative stress, and changes inenzymatic and metabolic pathways provide the bases for this bidirectional kidney?liver damage. In conclusion, knowing thecharacteristics of this kidney?liver crosstalk is crucial for handling the complications induced by this vicious circle.
