IMTIB 27019
INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Unidad Ejecutora - UE
artículos
Título:
Fluconazole treatment in severe ectopic cushing syndrome
Autor/es:
FAINSTEIN-DAY, PATRICIA; CANTEROS, TERESA M.; DE MIGUEL, VALERIA
Revista:
Endocrinology, Diabetes and Metabolism Case Reports
Editorial:
BioScientifica Ltd.
Referencias:
Año: 2019 vol. 2019
Resumen:
Severe Cushing syndrome (SCS) is considered an emergency that requires immediate treatment to lower serum cortisol levels. Fluconazole may be considered an alternative treatment in Cushing syndrome when ketoconazole is not tolerated or unavailable. We report a 39-year-old woman with a history of partial pancreaticoduodenectomy due to a periampullary neuroendocrine tumor with locoregional extension. Three years after surgery, she developed liver metastases and was started on 120 mg of lanreotide/month, despite which, liver metastases progressed in the following 6 months. The patient showed extreme fatigue, muscle weakness, delirium, moon face, hirsutism and severe proximal weakness. Laboratory tests showed anemia, hyperglycemia and severe hypokalemia. 24-h urinary free cortisol: 2152 nmol/day (reference range (RR):
