INVESTIGADORES
PASQUINELLI Virginia
congresos y reuniones científicas
Título:
Hypervirulent Clostridioides difficile BI/NAP1/027 strain regulated T cells responses in an vivo murine model
Autor/es:
HERNÁNDEZ DEL PINO RE; CAJIAO MF; BARBERO AM; CELANO J; ESTERMANN MA; ESPAÑOL LA; MORRO LS; MACHAIN M; PASQUINELLI V
Lugar:
San Miguel de Tucumán
Reunión:
Congreso; LXVII Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2019
Institución organizadora:
Sociedad Argentina de Inmunología (SAI)
Resumen:
Clostridioides difficile, the etiologic agent of antibiotic-associated diarrhea, is a Gram-positive, anaerobic, spore-forming bacterium. BI/NAP1/027 is a hypervirulent strain that has dramatically changed the epidemiology of C. difficile infection (CDI). Since antibiotic runs the risk of prolonged gut microbiota perturbation and so recurrence of infection, identification of key effector molecules of host immune response against CDI may provide new therapeutic targets and biomarkers to improve treatment and diagnoses.We used a murine model to study the adaptive immune response during CDI. After induction of dysbiosis, mice were infected with spores from BI/NAP1/027 strain. Infected mice evidenced typical CDI symptoms such as diarrhea, hunched posture, and weight loss (p
