INVESTIGADORES
PASQUINELLI Virginia
congresos y reuniones científicas
Título:
Signaling pathways that regulate restimulation-induced cell death in tuberculosis patients
Autor/es:
HERNÁNDEZ DEL PINO RE; ROVETTA AI; PELLEGRINI J; SOMOZA M; AMIANO N; PALMERO D; MALBRÁN A; GUTIÉRREZ M; PASQUINELLI V; GARCÍA VE
Lugar:
Mar del Plata
Reunión:
Congreso; LXII Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI) LIX Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC).; 2014
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC). Sociedad Argentina de Inmunología (SAI).
Resumen:
NK, T, B cell antigen (NTB-A) and SLAM associatedprotein (SAP) expression are required for T cell restimulation-induced cell death (RICD). We reported that T cells from Low responder (LR) tuberculosis (TB) patients displayed higher levels of SAP mRNA and protein than healthy donors (HD) and High responder (HR) TB patients. Here, we evaluated cell loss in restimulated cells to address whether SAP is directly required for RICD using X-linked lymphoproliferative (XLP) patients (SAP-deficient patients). XLP patients displayed between 35-50% cell loss after restimulation, while HD and HR patients showed 70-90% cell loss (p
