Regulation of cellular homeostasis by NTB-A/SAP pathway in Tuberculosis

HERNÁNDEZ DEL PINO RE; ROVETTA AI; ALVAREZ GI; PEÑA D; MUSELLA RM; PALMERO D; MALBRÁN A; PASQUINELLI V; GARCÍA VE

Cordoba

Taller; First Argentinean Spring Course in Advanced Immunology (ASCAI). Curso Pre-congreso organizado por la Sociedad Argentina de Inmunología (SAI) en su LXI Reunión Anual; 2013

Sociedad Argentina de Inmunología

NK, T, and B cell antigen (NTB-A) and SLAM associated protein (SAP) expression is required for T cell restimulation-induced cell death (RICD). X-linked lymphoproliferative (XLP) patients present a SAP inactivating mutation which causes a severe primary immunodeficiency. T cells from these patients produce high IFN-γ levels and are resistant to RICD. Previously, we reported that SAP interferes with M. tuberculosis (Mtb)-induced IFN-γ production. We investigated the role of the NTB-A/SAP pathway in the regulation of lymphocyte homeostasis on XLP individuals, healthy donors (HD) and tuberculosis (TB) patients (classified as Low and High responders (LR and HR) according to immune responses and disease severity). Significant increases on SAP mRNA levels were found after 5 days of Mtb stimulation (p