The IL17 rs2275913 Single Nucleotide Polymorphism (SNP) is associated with human Tuberculosis susceptibility in Argentina

ROLANDELLI A,; HERNANDEZ DEL PINO RE; ALVAREZ GI; PELLEGRINI JM; TATEOSIAN NL; AMIANO NO; PALMERO DJ; CASCO N; GUTIERREZ M; PASQUINELLI V; GARCÍA VE

CAPITAL FEDERAL

Congreso; IV Congreso de la Sociedad Lationoamericana de Inmunodeficiencias (LASID), LXIII Reunión de la Sociedad Argentina de Inmunología (SAI) y II Reunión FAIC (French-Argentinean Immunology Congress); 2015

LASID, SAI, FAIC.

Background. Interleukin 17A (IL-17) plays an important role in hostpathogeninteraction during Mycobacterium tuberculosis (Mtb) infection. Genetic variations in IL-17 gene may affect the immune response against this bacterium. The SNP rs2275913 (g/a) is the most studied nucleotide substitution in IL17Agene, but only one study reported the association of this SNP with tuberculosis susceptibility in a Spanish population. Here we investigated the relationship between rs2275913 SNP and tuberculosis susceptibility in Argentina and evaluated the functional implications of the substitution. Methods. 146 tuberculosis patients (TB) and 164 healthy donors (HD) were genotyped by ARMSPCR.IFNgamma and IL17A levels were analyzed by ELISA in plasma and supernatants fromperipheral blood mononuclear cells (PBMCs) stimulated with a Mtb lysate. Results. Significant differences in the allelic and genotypic (p