INVESTIGADORES
PASQUINELLI Virginia
congresos y reuniones científicas
Título:
Th17 immune response and costimulatory molecules modulation against hypervirulent BI/NAP1/027 C. difficile strain infection
Autor/es:
HERNÁNDEZ DEL PINO RE; ESPAÑOL LA; BARBERO AM; MORRO LS; VILLAFAÑE G; PALMA S; MACHAIN M; PALUMBO ML; GRUPPI A; PASQUINELLI V
Lugar:
Varadero
Reunión:
Congreso; Latin American and Caribbean Association for Immunology (ALACI); 2022
Institución organizadora:
ALAI- IUIS
Resumen:
Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea. The innate immune response plays a pivotal role against CDI. However, the function of intestinal CD4+ T cells during CDI remains uncertain. Moreover, key effector molecules like SLAM and ICOS may provide new therapeutic targets and biomarkers to improve treatment and diagnoses. We aim to characterize the gut adaptive immune response against CDI. C57/BL6 mice were treated with antibiotics and then infected with 105 spores of BI/NAP1/027 C. difficile strain. Infected mice showed typical CDI symptoms (p
