Characterizing mainstream and sidestream volatile emissions from heat-not-burn products

SLEIMAN, MOHAMAD; LUCIA CANCELADA; V.N. MONTESINOS; RUSSELL, MARION L.; X. TANG; DESTAILLATS, HUGO; L.A. GUNDEL; MARTA I. LITTER

Encuentro; SRNT 25th Annual Meeting; 2019

This study evaluated volatile emissions generated from the IQOS heat-not-burn cigarette. Three different ?heatsticks? were used inside a 200-L Teflon-coated environmental chamber following the Health Canada Intense (HCI) protocol. A broad range of volatile organic compounds (VOCs) present in mainstream and sidestream emissions were collected using sorbent tubes, which were subsequently analyzed by GC/MS with a thermal desorption inlet. Volatile carbonyls were captured into dinitrophenylhydrazine (DNPH)-coated silica cartridges, subsequently extracted with acetonitrile and analyzed by HPLC. A total of more than 70 VOCs were identified in mainstream emissions, and more than 100 VOCs in sidestream emissions. The delivery yield of these VOCs was compared with our previous determinations for electronic cigarettes. At the same time, IQOS yield was compared with data reported in the literature for conventional (combustion) cigarettes. In general, IQOS yields of carbonyls, aromatic compounds and amines (except for nicotine) were between one and two orders of magnitude lower than combustion cigarettes yields, but relatively similar to those of e-cigarettes. In addition, emissions from one of the three heatsticks, a mentholated product, were also characterized at different incubation temperatures in the range 180 ? 220 °C using a GC/MS with a headspace inlet. The incubation conditions were relevant to temperatures measured during IQOS operation. An increase in the emission levels of VOCs, together with changes in the relative concentrations of the principal species, were observed as the incubation temperature increased. The observed sensitivity with respect to the heating temperature suggests that emissions could vary significantly due to different use patterns, aging and soiling of the heating blade. The potential impact on secondhand exposures was evaluated by predicted indoor concentrations under various scenarios using measured sidestream VOCs and an estimate of exhaled mainstream VOCs emissions.