Alterations in Iron and Nitric Oxide Plasmatic Content in Endotoxemia Seems as Independent Events.

GALLEANO M; ROBELLO E; ROUSSEAU I; PUNTARULO S

Villa Carlos Paz, Córdoba

Congreso; 44th Annual Meeting Argentine Society for Biochemistry and Molecular Biology Research; 2008

The aim of this work was to identify the possible link between the increase in nitric oxide (NO) and the plasma Fe content in endotoxemia. Female Sprague-Dawley rats were injected ip with saline solution (C) or LPS (4 mg/kg) and measurements were done 6 h after injections. Blood NO level, detected by EPR as the complex NO-Hb, was significantIy higher in LPS as compared to C animals (22±2 and 0.8±0.5 AU respectively, p