INVESTIGADORES
NAZER Ezequiel
artículos
Título:
Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs
Autor/es:
ROMERO, AGUSTÍN; HEIDENREICH, ANA C.; ROMÁN, CAROLINA L.; ALGAÑARÁS, MACARENA; NAZER, EZEQUIEL; GAGLIARDINO, JUAN J.; MAIZTEGUI, BÁRBARA; FLORES, LUIS E.; RODRÍGUEZ-SEGUÍ, SANTIAGO A.
Revista:
Frontiers in Endocrinology
Editorial:
Frontiers
Referencias:
Año: 2023 vol. 14
Resumen:
Diabetes mellitus is characterized by chronic hyperglycemia with loss of β-cell function and mass. An attractive therapeutic approach to treat patients with diabetes in a non-invasive way is to harness the innate regenerative potential of the pancreas. The Islet Neogenesis-Associated Protein pentadecapeptide (INGAP-PP) has been shown to induce β-cell regeneration and improve their function in rodents. To investigate its possible mechanism of action, we report here the global transcriptional effects induced by the short-term INGAP-PP in vitro treatment of adult rat pancreatic islets.
