INVESTIGADORES
TOMAT Analia Lorena
artículos
Título:
Nitric oxide synthase blockade and body fluid volumes
Autor/es:
BALASZCZUK AM; TOMAT AL; BELLUCCI S; FELLET, A; ARRANZ C
Revista:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Editorial:
Asociación Basilera de Divulgación Científica
Referencias:
Lugar: San Pablo; Año: 2002 vol. 34 p. 131 - 134
ISSN:
0100-879X
Resumen:
The influence of chronic nitric oxide synthase inhibition with NGnitro-
L-arginine methyl ester (L-NAME) on body fluid distribution
was studied in male Wistar rats weighing 260-340 g. Extracellular,
interstitial and intracellular spaces, as well as plasma volume were
measured after a three-week treatment with L-NAME (»70 mg/kg per
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
L-arginine methyl ester (L-NAME) on body fluid distribution
was studied in male Wistar rats weighing 260-340 g. Extracellular,
interstitial and intracellular spaces, as well as plasma volume were
measured after a three-week treatment with L-NAME (»70 mg/kg per
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
L-arginine methyl ester (L-NAME) on body fluid distribution
was studied in male Wistar rats weighing 260-340 g. Extracellular,
interstitial and intracellular spaces, as well as plasma volume were
measured after a three-week treatment with L-NAME (»70 mg/kg per
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
Gnitro-
L-arginine methyl ester (L-NAME) on body fluid distribution
was studied in male Wistar rats weighing 260-340 g. Extracellular,
interstitial and intracellular spaces, as well as plasma volume were
measured after a three-week treatment with L-NAME (»70 mg/kg per
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
»70 mg/kg per
24 h in drinking water). An increase in extracellular space (16.1 ± 1.1
vs 13.7 ± 0.6 ml/100 g in control group, N = 12, P<0.01), interstitial
space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P<0.001) and
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P<0.001) and
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P<0.001) and
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
in the L-NAME group (N = 8). Plasma volume was lower in L-NAMEtreated
rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1 ml/
100 g, P<0.001). Blood volume was also lower in L-NAME-treated
rats (5.2 ± 0.3 ml/100 g) than in the control group (7.2 ± 0.3 ml/100 g,
P<0.001). The increase in total ratio of kidney wet weight to body
weight in the L-NAME group (903 ± 31 vs 773 ± 45 mg/100 g in
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show
that L-NAME-induced hypertension causes alterations in body fluid
distribution and in renal mass.
control group, P<0.01) but not in total kidney water suggests that this
experimental hypertension occurs with an increase in renal mass. The
fact that the heart weight to body weight ratio and the total heart water
remained constant indicates that, despite the presence of high blood
pressure, no modification in cardiac mass occurred. These data show