Preliminary results of first HPV primary screening private sector in Buenos Aires female population

JIMÉNEZ DEL TORO R; KREIMBERG K; CAMICIA G; CALDERAZZO PEREYRA J; SALANOVA R; PAUL L; POWAZNIAK Y

Cape Town

Conferencia; 31st International Papillomavirus Conference; 2017

Introduction: Studies show that infection caused by HPV is a direct cause of cervical cancer. From the 40 HPV types affecting ano-genital tract, 15 are considered of higher oncogenic risk. HPV16 and 18 account for 70% of cervical cancer cases. The objective of this study was to determine the prevalence of HPV genotypes and the correlation between DNA-PCR test and cytology. Methods: Women 25-65 years from Buenos Aires were included. HPV-DNA detection was performed with cobas(R) 4800 HPV Test, which detects and identifies HPV16, 18, and 12 other high risk types. Cytology (Pap) was performed according to standard procedures. Results: From the 329 analyzed samples, 21% were positive for HPV infection. Within positive cases, we could identify 23% HPV-16, 8% HPV-18 and 86% hr-HPV. The agreement between cytology and genotyping results was 85% (n=93) in normal cytology, 50% for LSIL (n=8), 100% for HSIL (n=2) and 50% for ASCUS (n=2). Graphic 1. Agreement between HPV test and cytology results. Discussion: Distribution of HPV genotypes was similar to published studies. However, percentage of HPV-16 was higher than expected (5 vs 3%), probably due to reduced sample size. From the 14 HPV positive cases with normal cytology, 6 resulted positive for HPV-16 and 1 for HPV-18. Based on cytology, these women with hr-HPV infections would have been dismissed from preventive diagnosis.