PERSONAL DE APOYO
PINILLA Oscar Andres
congresos y reuniones científicas
Título:
Physiologic cardiac hypertrophy: impact of its development upon a model of pathologic hypertrophy
Autor/es:
ENNIS IL; NOLLY MB; PINILLA OA; GARCIARENA CD; CARRANZA VB; PIAGGIO MR; ESCUDERO EM; CINGOLANI HE
Lugar:
Buenos Aires, Argentina
Reunión:
Congreso; World Congress of Cardiolgy; 2008
Resumen:
Pathologic cardiac hypertrophy (CH) is an independent risk factor for cardiovascular morbidity
and mortality. It usually leads to heart failure development. On the other hand, cardiac
hypertrophy induced by intense and periodical execersise training is an adaptive response of
the myocardium to the increase haemodinamic demand and of course it does not represent a
risk factor. The aim of the present work was to analize in spontaneously hypertensive rats (SHR)
the effect of intense exercise trainning (swiming, 90 min/day, 5 days a week during 2 months)
upon CH and cardiac function. Male SHR (5 month of age) were randomly assigned to a control
group ("C", no physical training) or the excersice group ("E", swimming rutine). Echocardiographic
studies of each animal were performed at day 1 and day 60 of the protocol. At the end
of the protocol the animals were euthanized and hearts kept for histological, biochemical and
molecular analizys. The 60 day swimming rutine induced a significant increase in left
ventricular mass determined by ecochardiography (3.02_0.07 in E vs. 2.76_0.07 mg/g in C;
p_0.02), however in the excersised animals a significant reduction in the expression of
molecular markers of CH was detected by real time RT-PCR: atrial natriuretic peptide (ANP, C:
100_19; E: 41_10 %, p_0.05) and myosin light chain-2 (MLC-2, C: 100_8; E: 61_9 %;
p_0.05). Moreover, exercise training improved cardiac function when measured by the
mid-ventricular shortening (C: 32.12_1.01; E: 36.03_1,34; p_0.05). The histological study
revealed a significant reduction in collagen fraction in the exercised animals. In conclusion, our
results suggest that intense and programmed exercise training is capable of inducing
physiological CH even in the presence of pathologic CH, leading to an improvement in the
histology, molecular pattern and yet more important in contractility. This finding could be
clinically relevant in the prevention of heart failure in patients with pathologic CH.