IPQA 26111
INSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS Y QUIMICA APLICADA
Unidad Ejecutora - UE
artículos
Título:
Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
Autor/es:
MICAELA A. MACCHIONE; ESTEBAN MATÍAS EUTI; MARIA ANGEL MUÑOZ-FERNANDEZ; CARLOS GUERRERO-BELTRAN; MARISA MARTINELLI; ANABELLA ROSSO; MIRIAM STRUMIA
Revista:
Scientific Reports
Editorial:
Scientific Reports
Referencias:
Año: 2019 vol. 9 p. 1 - 10
ISSN:
2045-2322
Resumen:
Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.
