Family history in hippocampal sclerosis

KAUFFMAN MARCELO; CONSALVO DAMIAN; SCHUSTER GUSTAVO; KOCHEN SILVIA

Santiago de Chile

Congreso; 11 Congreso Panamericano de Neurología; 2003

Introduction: Genetic factors seem to play a role in hippocampal sclerosis (HS). A high prevalence of febrile seizures, epilepsy and asymptomatic hippocampal alterations was reported in the families of these patients. Objectives: To analyze the presence of positive family history (FH) in a population of patients with HS. To investigate the association between FH and particular characteristics in temporal mesial volumetric measurement. Methods: FH let to the division of HS patients into two groups (FHS and NFHS). We compared the volumetric measurement of the right hippocampus (VRH), left hippocampus (VLH), right amygdala (RA), left amygdala (LA) and the ratio between the smaller and larger hippocampal volumes (HA) was calculated. Results: HS 83 patients; 46 women and 37 men; average age 37.72F10.9 years. FH in 19 cases (22%). FHS (n = 8) VRH 2307.5 F 444.45, VLH 2835F573.54, RA 2120F337.98, LA 2288.8F298.11, HA 0.6611F0.2583. NFHS (n = 22) VRH 2694F745.2, VLH 2492.7 F506.22, RA 1900 F 391.13, LA 1992.7F450.97, HA 0.7004F0.1196. The differences did not reach statistical significance. Conclusion: There are a positive FH in 22% of the cases without association with any particular characteristic in temporal mesial volumetric measurement.: Genetic factors seem to play a role in hippocampal sclerosis (HS). A high prevalence of febrile seizures, epilepsy and asymptomatic hippocampal alterations was reported in the families of these patients. Objectives: To analyze the presence of positive family history (FH) in a population of patients with HS. To investigate the association between FH and particular characteristics in temporal mesial volumetric measurement. Methods: FH let to the division of HS patients into two groups (FHS and NFHS). We compared the volumetric measurement of the right hippocampus (VRH), left hippocampus (VLH), right amygdala (RA), left amygdala (LA) and the ratio between the smaller and larger hippocampal volumes (HA) was calculated. Results: HS 83 patients; 46 women and 37 men; average age 37.72F10.9 years. FH in 19 cases (22%). FHS (n = 8) VRH 2307.5 F 444.45, VLH 2835F573.54, RA 2120F337.98, LA 2288.8F298.11, HA 0.6611F0.2583. NFHS (n = 22) VRH 2694F745.2, VLH 2492.7 F506.22, RA 1900 F 391.13, LA 1992.7F450.97, HA 0.7004F0.1196. The differences did not reach statistical significance. Conclusion: There are a positive FH in 22% of the cases without association with any particular characteristic in temporal mesial volumetric measurement.