INVESTIGADORES
DUPUY Fernando Gabriel
congresos y reuniones científicas
Título:
Effect of the charge on the interaction of L-cysteine and its esters with monolayers of DPPC
Autor/es:
ARIAS, JUAN MARCELO; DUPUY, FERNANDO G.; DIAZ, SONIA; BEN ALTABEF, AÍDA
Lugar:
La Plata
Reunión:
Congreso; XLVII Reunión Anual de la Sociedad Argentina de Biofísica; 2018
Institución organizadora:
Sociedad Argentina de Biofísica
Resumen:
The surface behavior of the aminoacid cysteine was studied by means of Langmuir monolayer technique The effect of charge on monolayers made of cysteine and three esters derivatives with dipalmitoylphosphatidylcholinewas investigated by preparing un buffered and buffered (pH 4 6 and 8) subphases Molecular interactions between the cysteine derivatives L cysteine, L cysteine ethyl ester, L cysteine methyl ester and N acetylcysteinewith DPPC monolayers were studied measuring the change in the surface tension upon aminoacid injection in the subphase whilst keeping lipid molecular density and lateral packing controlled The results indicate that, althoughthe different derivatives of cysteine presented low surface activity, they were able to favourably interact with DPPC monolayers Also, compression isotherms experiments in binary mixtures indicate that the more surface activecompounds stabilized the gel phase of DPPC The charge on cysteine and its derivatives increased the observed effects.
