INVESTIGADORES
ALVAREZ Lautaro Damian
artículos
Título:
Synthesis of C(1)?C(11) oxygen-bridged pregnanes
Autor/es:
ADRIANA S. VELEIRO; PAULA J. TAICH; LAUTARO D. ALVAREZ; PABLO H. DI CHENNA; GERARDO BURTON
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2005 vol. 46 p. 4235 - 4238
ISSN:
0040-4039
Resumen:
A general procedure for the synthesis of 1a,11a- and 1b,11a-epoxysteroids is described, using an intramolecular remote functionalization reaction involving the photolysis of 11a-hydroxysteroids in the presence of diacetoxyiodobenzene and iodine. Three 1,11-epoxypregnanes were prepared, two of them (compounds 10 and 14) are conformationally constrained analogues of steroidal hormones, compound 13 is a synthetic precursor of neurosteroids.
