INVESTIGADORES
ALVAREZ Lautaro Damian
artículos
Título:
Microwave assisted preparation of C(1)-C(11) oxygen-bridged pregnanes
Autor/es:
ALVAREZ, L.D.; SONEGO, J.M.; VELEIRO, A.S.; BURTON, G.
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 76 p. 1458 - 1464
ISSN:
0039-128X
Resumen:
1,11-Epoxysteroids may be obtained by an intramolecular remote functionalization using Suarez reagent (diacetoxyiodobenzene/I(2)) and irradiation with visible light. We have found that photolysis with visible light may be advantageously replaced by microwave irradiation to prepare 1,11-oxygen bridges resulting in higher yields and shorter reaction times especially in the case of sensitive substrates. Both methodologies were compared on a set of representative 11-α-hydroxypregnanes (3, 8, 10 and 11).
