Respiratory Commensal Bacteria Corynebacterium pseudodiphtheriticum Improves Resistance of Infant Mice to Respiratory Syncytial Virus and Streptococcus pneumoniae Superinfection

PAULRAJ KANMANI; PATRICIA CLUA; VIZOSO-PINTO, MARIA G.; CECILIA RODRÍGUEZ; ALVAREZ, SUSANA; VYACHESLAV MELNIKOV; HIDEKI TAKAHASHI; HARUKI KITAZAWA; VILLENA, JULIO

NEXT-GENERATION PROBIOTICS: FROM COMMENSAL BACTERIA TO NOVEL DRUGS AND FOOD SUPPLEMENTS

Frontiers

Año: 2019; p. 81 - 94

The concept of traditional probiotics is originally based on the observation that the regularconsumption of fermented dairy products with lactic acid bacteria was associated with enhancedhealth and longevity in elderly Bulgarian people. Since then, the term probiotic has been linked tobeneficial bacteria for the host health (Hill et al., 2014). The probiotics field has exploded in the lastyears due to the increased knowledge of the human gut microbiota and the awareness about healthimplication of dysbiosis. This new trend highlights that the use of commensal bacteria as probioticsis the natural way to restore a healthy homeostasis situation within the gastrointestinal tract (GIT)opening the door to a new kind of probiotics commonly termed Next-Generation Probiotics (NGP)(Martin and Langella, 2019).The current Research Topic covers a collection of reviews, mini-reviews, perspectives, opinion,methods, and original research articles focused on the NGPs field. In this sense, two reviews havebeen focused on the no-scientific concerns. In the first one, El Hage et al. cover current perspectiveson the development and assessment of NGPs and the approaches that industry and stakeholdersmust consider for a successful outcome. In the second one, Brodmann et al. analyze the safety ofnovel microbes for human consumption with a special focus on the regulatory framework.