Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1

REPPETTI JULIETA; ETCHEVERRY TOMAS; SIERRA MATÍAS N.; DAMIANO ALICIA E; FARINA MARIANA; MARTINEZ NORA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2019

0006-291X

In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolarstress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective cation channel that is activated by hyperosmolarity and participates in many cellular processes. TPRV-1 is expressed in human placenta at term.Here, we evaluated the expression of TRPV-1 in first trimester extravillous trophoblast cells and its participation in the survival of these cells exposed to hyperosmolar stress.Our results showed that hyperosmolar stress up-regulates the expression of TRPV-1 and induces the apoptosis in Swan 71 cells. In addition, the inhibition of TRPV-1 abrogates the apoptotic events.