A BRUCELLA PROTEASE INHIBITOR IS A USEFULL ADJUVANT IN ORAL VACCINE FORMULATIONS

RISSO, GS; IBAÑEZ AE; CORIA LM; PASQUEVICH KA; DELPINO MV; BRIONES G; CASSATARO J

Congreso; XXXVII Congress of Brazilian society of immunology 2012; 2012

Brazilian society of immunology

Introduction: Previous results showed that a Brucella protein (BP) administered by the oral route and without adjuvants induced protection against oral Brucella challenge. These results indicated that BP had self-adjuvant properties and prompted us to study its potential application as adjuvant for other antigens (Ags).Methods and Results: Our results indicated that BP is a broad spectrum protease inhibitor with a stronger activity against serine proteases secreted by the pancreas to the intestine (elastase, trypsine and alpha chymotrypsin; p