ENYS   25968
UNIDAD EJECUTORA DE ESTUDIOS EN NEUROCIENCIAS Y SISTEMAS COMPLEJOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
OSCILLATORY BRAIN ACTIVITY INDUCED BY TARGET MEMORY REACTIVATIONS DURING SLOW WAVE SLEEP: PRELIMINARY RESULTS
Autor/es:
MALEN MOYANO; CECILIA FORCATO; IGNACIO BRUSCO; SUSANNE DIEKELMANN
Reunión:
Congreso; XXXIV Reunión Anual SAN 2019; 2019
Resumen:
Consolidated memories can be reactivated by a reminder of the original memory; followed by a process of re-stabilization known as reconsolidation. Sleep is known to support the consolidation of newly encoded memories and we have previously demonstrated that sleep has a beneficial effect on reconsolidation and that the slow wave activity (0.5-8Hz) during No-REM sleep correlates with memory re-stabilization. Several studies, induced reactivations during the sleep period after acquision, by presenting cues previously associated with the learned material, showing an enhanced performance after reactivations. However, only one study in mice provides the first evidence the consolidated memories can be also strengthened by presenting cues during sleep and that this process is mediated by labilization/restabilization mechanisms. So, here we test if a human consolidated declarative memory can be modified during Slow Wave Sleep by presenting auditory cues associated to the learned material. For that, participants were trained on day 1 in a sound-word paradigm. On day 2 day slept for 90 minutes and they received or not, during Slow Wave Sleep, reminders of the learned associations. 30 min after being awaken they were tested. Participants that received reminders during (SWS) showed a better performance than the no reactivated group. Reactivation during SWS were associated to an increase in theta and spindle power during syllable-cue presentation.