Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor

VALLES, ANA SOFIA; GARBUS, I; BARRANTES FJ

NEUROREPORT

Lippincott Williams & Wilkins

Año: 2007 vol. 18 p. 45 - 50

0959-4965

Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies.We studied its possible interactionwith channels other thanits known therapeutic target, thevoltage-gated sodium channel, using the adultmuscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closedtime component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on themuscle nicotinic acetylcholine receptor. NeuroReport mean burst duration and (c) increase in the area of a new closedtime component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on themuscle nicotinic acetylcholine receptor. NeuroReport mean burst duration and (c) increase in the area of a new closedtime component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on themuscle nicotinic acetylcholine receptor. NeuroReport 18:45^50c 2007 LippincottWilliams &Wilkins.c 2007 LippincottWilliams &Wilkins.