Effects of a dietary treatment with olive oil in placental mTOR pathway in a rat model of gestational diabetes mellitus.

LEVIEUX C, GOMEZ RIBOT D, HEINECKE MF, JAWERBAUM A, CAPOBIANCO E.

Congreso; Reunión Conjunta de Sociedades de Biociencia; 2017

We previously found intrauterine programming of gestational diabetes (GDM) in the offspring of pregestational diabetic rats. Placentas from GDM rats show overactivation of mechanistic target of rapamycin (mTOR) signaling pathways (mTORC1 and mTORC2), involved in fetal overnutrition and overgrowth. Maternal diets supplemented with olive oil have previously shown beneficial metabolic effects in the placenta in pregestational diabetic experimental models. Aim: to evaluate the effect of a maternal dietary treatment with olive oil in term placentas from GDM rats. Methods: Offspring from control and pregestational diabetic rats were mated with control males, and fed with a standard diet or a diet enriched in 6% olive oil (OO) from day 1 to 21 of gestation. On day 21 of gestation, metabolic parameters and placental mTOR signaling pathways (Western blot) were evaluated.Results: During gestation the offspring of diabetic rats develops GDM, which was not prevented by the OO diet. In the placenta, the decrease in the total 4EBP1 expression in the placentas from GDM rats (44%, p