- Paternal Programming: Sex-dependent Effects In The Placenta Of Fetuses From Male Diabetic Rats.

DAIANA FORNES, FLORENCIA HEINECKE, VERÓNICA WHITE, ALICIA JAWERBAUM, EVANGELINA CAPOBIANCO.

Congreso; 4th Meeting of DOHAD Latin American Chapter: One World, One Health.; 2020

BackgroundPaternal exposure to diabetes can lead to the transmission of metabolic disorders in the offspring. Our aim was to assess sex-dependent lipid alterations in the placenta of fetuses from diabetic males.MethodsControl and type 2 diabetic male rats (diabetes obtained by intrauterine programming in the offspring of streptozotocin-induced diabetic rats, glycemia: 140-190 mg/dL) were mated with control female rats. On day 21 of gestation, the placenta of male and female fetuses was obtained for the evaluation of lipid levels (by TLC) and mRNA of genes involved in lipid metabolism (by RT-qPCR).ResultsFetal weight was increased in both males and females of diabetic group (15%, p